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This growing global distribution highlights the urgent need for early detection, preventive screening, and integrative approaches that address both disease management and long-term quality of life [3][2]

Furthermore, the threshold effect is consistent with the concept that methionine synthase activity may become saturated beyond a certain B12 concentration [17], explaining the diminishing returns observed at higher levels

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They can help improve skin texture, enhance hydration, and even support a more even tone