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Using a combination of RNAseq and metabolomics analysis of mouse liver samples taken 3 h and 6 h after introduction of dietary MR, in conjunction with in vitro analysis of methionine-restricted HepG2 cells, our data suggest that the rapid initial decrease in hepatic methionine decreases ternary complex formation, slows overall translation, and induces an ISR that is modulated by mTOR, Erk1/2, and ATF4

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Aflatoxins are acutely toxic, immunosuppressive, mutagenic, teratogenic and carcinogenic compounds (classified as group 1 carcinogens according to the

Transitioning to Weekly and Monthly Regimens After the first week, the dose is changed to weekly injections for a month

Front Physiol 12:680544 Deng F, Zhao BC, Yang X et al (2021) The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis

The foam cells secrete inflammatory substances that promote the production of a tough fibrous matrix that caps the fatty core to generate a plaque