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This is vastly more dilute than topical formulations, but isolated cells in culture have direct peptide access without any barrier to penetration

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2018 Feb 13;9:35

In addition, we note that beginning with the FY 2022 IPPS/LTCH PPS final rule, we refer to this adjustment as the productivity adjustment rather than the MFP adjustment to more closely track the statutory language in section 1886(b)(3)(B)(xi)(II) of the Act

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