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Study by Wall et al.[9] further highlights that carnitine supplementation shifts fuel utilization during exercise, decreasing reliance on glycogen and increasing fatty acid oxidation

[DOI] [PubMed] [Google Scholar] 99.Calabrese V, Ravagna A, Colombrita C, Scapagnini G, Guagliano E, Calvani M, Butterfield DA, Giuffrida Stella AM

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the compound of the invention represents a peptide which comprises 6, 7 or 8 amino acids linked in a chain and can be represented by the following formula: the compound of the invention can be represented by the following formula: AA 1 is Glu AA 2 is Glu AA 3 is Met AA 4 is Gln AA 5 is Arg AA 6 is Arg 1 of AA 1 , AA 2 , AA 3 , AA 4 , AA 5 and AA 6 is replaced providing that AA 1 is an amino acid selected from the group consisting of Asp, Gln and Asn

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It is widely known that mitochondrial dysfunction (high ROS production, apoptotic cells, decreased m, and low cellular ATP levels) boosts the pathogenesis of KOA because it involves lipid homeostasis and cytokine release and promotes cell apoptosis [14, 15]