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Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MdP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, et al

There are many possible neuroprotective benefits for those who may suffer from brain damage or even cognitive diseases like Alzheimers, such as preventing disease development and helping to recover brain function after traumatic injury

However, this effect may be due to the large amount of cystine provided in the control conditions (208 M), as reduction of cystine levels in the medium did not impair growth but abolished intracellular cysteine and cystine levels (Extended Data Fig

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During long-term human fasting, decreased release of skeletal muscle pyruvate into the bloodstream has been hypothesized to lead to reductive shifts in the malate/pyruvate and pyruvate/lactate in the blood and other tissues throughout the body (Owen et al., 1967, 1969)