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It's important to remember that this pain is not just normal period cramps because it happens on its own

M1 macrophages are characterized by enhanced aerobic glycolysis, while in M2 macrophages elevated TCA cycle and OXPHOS are observed

A recent network meta-analysis took into consideration all the available treatments for UC (except ustekinumab) and concluded that tofacitinib is an efficacious treatment for moderate-to-severe active UC and is likely to be a cost-effective use of NHS resources[105]

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