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Like NOX5, DUOX enzymes are activated by Ca 2+

In a phase I trial of locoregional IL13R2 CAR Ts in recurrent high-grade glioma, treatment was feasible, toxicities were mostly low grade, and objective responses, including durable regressions, occurred without a consistent off-tumor injury signal [134] An ongoing phase I trial is evaluating IL13R2 CAR Ts in stage IIIC/IV melanoma and other IL13R2-positive solid tumors, but melanoma-specific efficacy data have not yet been reported [133]

In explaining its decision, the agency flagged concerns about complexities with regard to peptide-related impurities and active pharmaceutical ingredient (API) characterization, the potential for aggregation and a lack of human safety data

To mitigate such a decline, the patient should be adequately assessed and treated by a dedicated team of specialists, which should also include trained psychosexologists and/or an expert in sexual medicine

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