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What particularly stood out in Jerne's mind was an experiment conducted in 1943 by Salvador Luria, an Italian-American physician and microbial geneticist, and Delbrck

Freund P, Wheeler-Kingshott CA, Nagy Z, Gorgoraptis N, Weiskopf N, Friston K, et al

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In this fashion, we hope to provide data that will support our conclusion that the intestinal paracellular space is a major route of transport of water and small solutes such as ions and small soluble organic molecules between the lumen and submucosal space, and not a means by which large molecules, lipophilic substances, or macromolecular structures such as proteins, particulate matter, or intact bacteria are absorbed

In clinical treatment of tumors, a key goal is to decrease toxicity and resistance of anti-tumor drugs by regulating low expression of GGT (22) and high expression of ChaC1 (65)

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