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Nearly half of the participants retained clinically meaningful weight loss even after treatment ended

(MMP)

Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium

In the late 1960s, others described mitochondrial abnormalities following cuprizone consumption in the mouse liver [26]

Standard break periods run 4-6 weeks, roughly half the length of the preceding cycle

In the intermediate phase, spanning 1 to 3 weeks, the loss of oligodendrocytes and activation of glial cells continue, with signs of demyelination and acute axonal pathology becoming evident (Crawford, 2009