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Human TRX has been initially identified as a factor responsible for induction of the A subunit of interleukin-2 receptor which is now known to be under the control of NFKB

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A recent study examined the association between on-treatment weight loss and risk of DILI from tuberculosis treatment and reported that weight loss of 2 kg or more within 4 weeks, concomitant hepatitis C, older age and multi-drug resistant TB were independently associated risk factors [40]