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Although the specific epigenetic regulatory mechanisms remain incompletely understood, evidence suggests that epigenetic factors, including miRNAs and RNA methylation, may play a role in the therapeutic process by regulating key genes associated with ferroptosis, such as GPX4 and SLC7A11 (200)

This parallels the emerging therapeutic potential in animals, where GPX4-regulated ferroptosis is being explored as a strategy for treating diseases such as cancer (Yang et al., 2014

This gene is mapped onto the X chromosome at the Xq28 band and codes for the G6PD enzyme

overexpressing TaCOPT3D in wheat decreases ROS levels and enhances antioxidant enzyme activity under Cd stress

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doi: 10.1016/S0140-6736(17)31222-9