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Vitamin B12 is critical for the formation of healthy red blood cells and the maintenance of nerve cells, preventing conditions like anemia and nerve damage

Patients with DKD also exhibit increased mitochondrial division, resulting in mitochondrial fragmentation, uneven mtDNA distribution, reduced expression of enzyme complexes in the ETC, decreased OXPHOS activity, and enhanced glycolysis as a compensatory mechanism [35, 36]

In addition to elevated body temperature, the mammalian host environment presents additional stressors that could also represent significant fitness bottlenecks to C