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One interesting and unanticipated finding is the increased nebulizer and LABA/ICS use in unobstructed smokers with HHs that was independent of both dyspnea perception according to the mMRC and the presence of cough or phlegm, lending weight to the idea that acid reflux in the lower esophagus affects pulmonary function

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No significant organ toxicity has been observed in standard histological analyses of animals treated with therapeutic-range doses