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While this characteristic of diselenide bonds is excellent when exposed to the reducing environment of tumors, as it enhances drug release, it also means that diselenide bonds have lower stability and can lead to the leakage of drugs when incorporated into a drug delivery system due to disintegration during circulation [29,33]

At the study endpoint, after 12 h of fasting, mice were euthanized by intraperitoneal injection of 3% sodium pentobarbital (60 mg/kg)