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3.3.4 HIF-1 mediated angiogenesis, metastasis and invasion Under hypoxic conditions, HIF-1 regulates a vast set of genes and pro-angiogenic factors both in tumor mass and vascular endothelial cells, including vascular endothelial growth factor (VEGF) (Simon et al., 2008), stromal-derived factor-1 (SDF-1) (Reinmuth et al., 2001)

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However, the root cause approach also emphasizes getting the right kind of protein to fulfill our amino acid needs, optimizing low stomach acid levels, as well as addressing nutrient deficiencies and issues related to MTHFR gene variations

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