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The interaction between FOXO4 and p53 within the nucleus plays a crucial role in the survival of both normal and senescent cancer cells 25,34

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Access this chapter Subscribe and save Buy Now Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Abbreviations GSH: Glutathione GSSG: Oxidised glutathione ROS: Reactive oxygen species References Aon MA, Cortassa S, Maack C, ORourke B (2007) Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status

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Compared to the sham group, DMM-operated joints exhibited severe articular surface erosion, fissured cartilage layers and proteoglycan depletion, as evidenced by diminished SO-FG staining intensity