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In contrast, effector T cells, NK cells, and other antitumor immune cells struggle to effectively enter the tumor interior owing to the abnormal vascular structures and the selective barrier functions of endothelial cells

There is a switch to anaerobic metabolism, lactic acid is produced and this results in the symptom of angina

In: Ross A, Caballero B, Cousins R, Tucker K, Ziegler T, eds

ab14713, Abcam), NDUFA10 (1:1,000 dilution, cat

doi: 10.1039/b715278g

We next performed a structural similarity search across our in-house compound collection, as well as on commercial small-molecule libraries (1,000,000 compounds) and identified 141 additional hits, which were screened in the high-throughput activity assay at a single concentration of 10 M