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Description

Chen J, Wei D, Lim P-E

When aging switches on Alzheimers

properties that many proposed drugs failed to reach

Consistent with expectations, bona fide p53 targets including HDM2 and CDKN1A were among the most highly up-regulated genes in Control cells, whereas genes known to be negatively regulated by p53, such as E2F2 , were strongly down-regulated (el-Deiry et al, 1993