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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

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These antioxidant systems include the GPX4 system, free radical scavenging antioxidant systems (such as the FSP1-COQH2 system, DHODH-CoQH2 system, and GCH1-BH4 system), and membrane repair systems ( Figure 1 )