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Additional restriction to immune access is conferred by physical barriers of structural ECM remodeling, whereby tumor-derived discoidin domain receptor 1 fragments realign collagen fibers, forming physical barriers that impede immune cell penetration (177)

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Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A (2019) NLRP3 inflammasome activation drives tau pathology