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doi: 10.1038/s41564-019-0540-4

Gut 68 , 22282237 (2019)

35 (10), e21871

Galunisertib (75 mg/kg) and/or devimistat (25 mg/kg) were administered intraperitoneally every 3 days

mTORC1 phosphorylates the hydrophobic motif site Thr389 of S6K1, allowing it to be further phosphorylated and activated by PDK1 (133)

Bioactive compounds have a wealth of pharmacological activities, including anti-inflammatory [230], antioxidant [49], anti-cancer [5], and protection of intestinal immune homeostasis[287]