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The We Card program is widely accepted across the country as the premier sales training and education program working with retailers, trade associations, government agencies, community groups and others to prevent underage access to tobacco and other age-restricted products

The couple went on to have two children of their own, Susan and Tim

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Over time, the brain adjusts to the presence of nicotine and necessitates higher doses to achieve the same effecta phenomenon known as tolerance

Pleiotropy was assessed using MR-PRESSO, and directional pleiotropy was assessed using the intercept for MR Egger regression (Supplementary Table 7)

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