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Adiponectin, the most abundant adipokine in circulation [220], exerts its biological effects via two primary receptors (AdipoR1 and AdipoR2) [221], these receptors exhibit differential expression patterns across hepatic cell populations, including hepatocytes, HSCs, and KCs, mediating beneficial effects such as anti-inflammatory responses and anti-fibrotic actions [222, 223]

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Therefore, the 4 4 factorial approach demonstrated that the interactions between selenium and iodine in basil biofortification are predominantly synergistic, enhancing nutrient accumulation, antioxidant defense, pigment synthesis, and essential oil quality

Galli SJ, Maurer M, Lantz CS