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While coffee likely won't "ruin" the supplement, the acidity and the presence of caffeine might speed up digestion, potentially reducing the time the glutathione has to be absorbed in the gut

Glutathione, often referred to as the master antioxidant, is essential for various functions, including detoxification, skin health, immunity, and liver support

But I do think just like objectively it's changing

If the solution is cloudy or has visible particles after 5 minutes of gentle swirling, the peptide may be degraded

Possible issues may include mild irritation, itching, dryness, or sensitivity, especially if the formula also contains alcohol, fragrance, exfoliating acids, or other strong actives

No serious adverse events in reviewed trials