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AOD-9604 and the beta3-adrenergic receptor pathway Chronic AOD-9604 administration in obese rodent models, specifically 2 mg/kg body weight daily via intraperitoneal injection for 14 days, upregulates beta3-AR RNA expression in white and brown adipose tissue to levels observed in lean mice

In mouse models of diabetic aortas, CD38 inhibition improved endothelium-independent contraction and vascular remodeling associated with NLRP3 inhibition [33]

3 The latter affects blood formation, leading to anaemia, a hallmark sign of B12 deficiency

The results can last anywhere from a few days to a few weeks

The study also highlighted AOD9604s influence on fat metabolism and energy expenditure, and its interaction with 3-adrenergic pathways [2]

MD Patrick Tyrance, Jr