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Furthermore, OHP causes damage to both neuronal and nonneuronal mitochondria, leading to oxidative stress burden mediated by the redox-sensitive TRPA1 channels, which correlate with OHP-induced cold and mechanical hypersensitivity [71, 115,116,117]

eBioMedicine (2022) 76:103861

Cardiomyocytes are formidable protein synthesis factories, producing around 14,000 proteins, rendering them particularly vulnerable to accumulating toxic levels of misfolded proteins in times of stress, such as in AF due to the rapid activation rates and enhanced mechanical and metabolic stress [8]

Indeed, proteasome-dependent proteolysis of carbonylated proteins that were extensively present in late log phase epimastigote cultures was suggested to signal metacyclogenesis (Cardoso et al., Nucleotides Synthesis and DNA Replication Cellular DNA synthesis and proliferation, as well as DNA repair mechanisms depend on the production of a balanced supply of deoxyribonucleotides (dNTPs)

Excessive hair loss or thinning hair may indicate an underlying issue or disrupted hair growth cycle

Measuring autophagosome flux