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Consistently, HIF1A also promotes GSH synthesis through transcriptional activation of GCLM and SLC7A11 , and pharmacological inhibition of SLC7A11 with erastin or sorafenib exacerbates cuproptosis 177,178

Surprisingly, we still detected an induction effect of DMF on most of the factors studied despite NRF2 silencing (Fig

Ironing out the details of ferroptosis

(2) Gastrointestinal GPx (GPx2) is only found in the cytosol and nucleus of the gastrointestinal tract

The internalization of iron by macrophages can modulate macrophage activity towards a pro-inflammatory phenotype, which may also depend on the pathway of iron intake

Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice