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The glycemic variability measured as the mean amplitude of glucose excursions (MAGE) significantly ( p = 0.004) reduced (High-carb = 1.8%, Low-carb = 0.5%), in contrast, non-significant ( p = 0.08) improvements in time in range (TIR-%) were observed in a low-carb group (High carb = 8.7%, Low-carb = 3.7%)

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42 Quantification of 8-oxo-dG in DNA was performed using mass spectrometry/liquid chromatography on a LCQ Advantage MAX system (Thermo Electron Corporation, Waltham, MA, USA) and expressed as pmol per mg DNA