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Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Because that figure comes from rodent research, many start patients at the low end (about 5 mcg/kg or a flat 250 mcg) and adjust over one to two weeks

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Through knowledge obtained by their genetic SNPs, patients can address inconsistencies in their one-carbon metabolism by supplementing nutrients in which they are deficient, or that encourage bypassing problematic aspects of the cycle, such as folinic acid, in order to optimize the efficiency of the methylation and related cycles

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