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In a depleted body, the ROS accumulate, which can cause immediate mitochondrial damage and trigger the severe, delayed symptom flares characteristic of PEM

The kidneys detect this decreased oxygen tension and respond by increasing the release of erythropoietin

Nicotinamide mononucleotide combined with Lactobacillus fermentum TKSN041 reduces the photoaging damage in murine skin by activating AMPK signaling pathway