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More recently, a phase 1 clinical trial with the Fc containing bispecific anti-EpCAM x anti-CD3 antibody catumaxomab (Removab) was terminated following a patient fatality, underlining the potential severity of Fc-enhanced immune stimulation 7 and requirement to mitigate adverse effects such as cytokine release syndrome and close monitoring of clinical trials with immune-stimulatory drugs 8,9

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