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Although this has never been described in the literature for this infectious model of toxoplasmosis, hypothermia is the most commonly reported predictor of mice imminent death in several infectious model 46

These pathological changes result in neuronal apoptosis and structural damage in nerves, including microtubular disruption and demyelination [111]

Furthermore, it decreased the expression of -SMA and induced apoptosis in HSCs, which contributed to the mitigation of fibrosis progression in vivo

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doi: 10.1371/journal.pgen.1004745 81 LiS.ShenL.HuP.LiuQ.ZhuX.Qianet al