Pharmacodynamic Effects and Duration Despite measurable plasma clearance, pharmacodynamic effects extend well beyond plasma half-life[20]: Weight loss effects continue throughout treatment with no plateau observed within 48-week study periods Glycemic improvements persist between weekly doses with stable glucose control Appetite suppression effects remain consistent throughout dosing intervals Tissue receptor occupancy likely exceeds plasma peptide concentrations This disconnect between pharmacokinetics and pharmacodynamics suggests prolonged receptor engagement, tissue depot effects, or persistent downstream signaling cascade activation
An immediate and then sustained effect on pressure in lower esophageal sphincter, and a postponed effect on pyloric sphincter after either 0.5 mg/kg or 1.0 mg/kg intraperitoneal challenge (white bars), pyloric sphincter seems to be less affected
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Sources & References FDA PCAC Meeting Announcement (July 23-24, 2026) PBS: FDA to Weigh Easing Limits on Peptides Favored by RFK Jr
Marks are less fine (0.1 mL), so it's a bit less precise for small doses
No pseudoscience
