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Disease coverage of human genome-wide association studies and pharmaceutical research and development

Occup Environ Med J Indones

doi: 10.1093/ajcn/80.1.38 30

Abbreviations ALI: Acute lung injury ACE: Angiotensin converting enzyme ARDS: Acute respiratory distress syndrome COPD: Chronic obstructive pulmonary disease CF: Cystic fibrosis CFTR: Cystic fibrosis transmembrane regulator CHD: Coronary heart disease IL: Interleukins IPF: Idiopathic pulmonary fibrosis MMP: Matrix metalloproteinase MAPK: Mitogen-activated protein kinase NF-kB: Nuclear factor-kappa B ROS: Reactive oxygen species RCT: Randomized clinical studies SARS-CoV-2: Severe acute respiratory syndrome- corona virus-2 TB: Tuberculosis TGF-: Transforming growth factor-beta TNF-: Tumor necrosis factor-alpha Th: T-Helper cells TLRs: Toll like receptors References Maes K, Serr J, Mathyssen C, Janssens W, Gayan-Ramirez G

(2003) 284:L42030

Moreover, another study by Sagrillo-Fagundes and his group found that melatonin significantly regulated autophagy and inflammation in primary trophoblast cells that were exposed to a hypoxic/reoxygenation environment, mimicking preeclamptic pregnancy, thus reducing apoptosis in these cells