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The edgeR package was used for paired comparison (progression vs pre-treatment) for each patient

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Subsequently, iron is released from transferrin and undergoes reduction to its divalent form by lysosomal reductases before being transported into the cytosol via divalent metal transporter 1 (DMT1) and transient receptor potential mucolipin (TRPML1/2), ultimately entering the cellular labile iron pool (LIP) [97]