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Research has shown that in HGSOC with a deficiency of tumor-infiltrating lymphocytes, EZH2 expression in cisplatin-resistant tumors is nearly twice that of normal tumors ( The high intratumoral heterogeneity (ITH) in HGSOC results in diverse molecular characteristics at different stages, consequently affecting its sensitivity and resistance to chemotherapy ( The composition and structure of the tumor microenvironment directly influence drug delivery efficiency