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However, in mouse adipocytes, H 2 S promotes adipogenesis by activating PPAR, where when CSE is deficient, mice show resistance to FDH-induced obesity (98)

The traditional herbal medicine, HangAmDan-B (HAD-B), reduces LPS-induced NO and PGE2 production in macrophages by blocking ATF2 phosphorylation, consequently limiting tumor-promoting activity of TAMs in gastric and colorectal cancers (166)

Subsequent studies identified GPX4 as a pivotal enzyme that prevents lipid peroxidation, with its inhibition promoting ferroptosis, emphasizing its central role in regulating this cell death process [7]