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While it promotes healthy collagen, it also downregulates pro-fibrotic factors and excessive collagen synthesis

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63 Additionally, the flexibility and selectivity of microfluidics technology, combined with the hydrogel degradation method using alginate and methacrylated gelatin, have resulted in the formation of multivalve structures of multimolecular microparticles with excellent adhesive capabilities

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IGF-1 availability is tightly regulated by the so-called insulin-like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF-1R) [9395]