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Bioactivation mechanism of S-(3-oxopropyl)-N-acetyl-L-cysteine, the mercapturic acid of acrolein

Similarly, oral administration of steviol glycosides at doses up to 1,880 mg/kg for 4 weeks caused only mild increases in oxidative damage and chromosomal abnormalities in mice, whereas no genotoxic effects were observed at doses as high as 8,000 mg/kg in vivo (Orellana-Paucar, 2023)