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PMID 3722679

Patients receiving botulinum toxin, for example, for epiphora ceased therapy prior to entering the program

Long-term human safety has not been fully established

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PT-141 activation of mPOA neurons appears to initiate downstream signaling cascades that: Enhance processing of sexual stimuli and context Increase neural responsiveness to arousal cues Facilitate coordination of sexual behavior patterns Modulate autonomic and endocrine responses Dopaminergic System Interactions Evidence from animal studies suggests PT-141s effects may involve modulation of dopamine signaling in brain regions controlling sexual function