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Researchers conducting in vitro or cell-based assays in particular should confirm low endotoxin levels in any BPC-157 peptide preparation before use, as cellular assay systems are particularly sensitive to lipopolysaccharide contamination artifacts

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Such heterogeneity among studies impedes cross-comparison and prevents the development of evidence-based therapeutic protocols

In 2014, a paper in the *Journal of Pharmacology and Experimental Therapeutics* laid out dihexa's proposed mechanism that it works by binding hepatocyte growth factor and activating the c-Met system to build synapses

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