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Another well-known African medicinal plant, Sutherlandia frutescens (commonly known as cancer bush), is native to Southern Africa and contains flavonoids and triterpenoids that have demonstrated immune-boosting and anti-inflammatory effects [75]

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Compound 44 exhibited the highest docking score with a binding energy of 10.36 kcal/mol and formed five crucial hydrogen bonds with Gly225, Phe113, and the NADPH cofactor as well as stable binding throughout the simulation (RMSD 0.250.35 nm)

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With regard to the expression of vascular endothelial growth factor and epidermal growth factor like domain multiple 6 (biomarkers of angiogenesis), both alginate and zinc hydrogels, with and without CBD, were shown to increase their expression, but little or no significant difference was observed between them