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Under aerobic conditions, the primary activities of PDC and OGDHC enzyme complexes become key metabolic regulatory nodes as they control: (i) for PDC, the conversion of pyruvate to acetyl-CoA, a key TCA carbon source (Fig

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Genetic inactivation of RIPK1 improves RGC survival and preserves retinal function in the preclinical glaucoma models of optic nerve crush (ONC) and IRI, which indicate that RIPK1 plays an important role in modulating neuroinflammation and that inhibiting RIPK1 activity may provide a neuroprotective therapy for glaucoma 66