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Similarly, the small molecule USP24-i-101 facilitates autophagy-dependent PD-L1 degradation and may help mitigate acquired resistance to ICIs (140)

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Mena P, Cirlini M, Tassotti M, Herrlinger KA, DallAsta C, Del Rio D

For example, we here show that the lysosomal CD68 is expressed in many populations of microglia, including non-phagocytic cells and, in the past, we observed increased expression of CD68 during inflammatory conditions 11

The normal cellular function of C9orf72 is related to vesicular trafficking and autophagy (Farg et al., 2014) whereas SOD1 is an antioxidant enzyme that mediates detoxification of the superoxide anion radical (