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Cryo-EM data processing All processing was performed in CryoSPARC v.4.4.1 69

Norepinephrine is normally released from nerve terminal vesicles in response to sympathetic nerve action potentials, and is lowered through presynaptic receptors by the 1 AR antagonists

10.1186/1999-3110-55-7 28 GaoF.ChenJ.MaT.LiH.WangN.LiZ.et al

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These data suggest that the increased risk of anemia observed in patients with T2D treated with metformin cannot be explained by vitamin B12 deficiency