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Comparing H2 Blockers to PPIs in B12 Depletion H2 receptor antagonists and proton pump inhibitors (PPIs) both reduce stomach acid

Unbalanced chain accumulation dominates the clinical phenotype

nerves take time to heal, but adequate B vitamins remove the roadblock to nerve repair

Recommended Dosing The starting dose of hydroxocobalamin for adults is 5 g administered as an intravenous infusion over 15 minutes (approximately 15 mL/min)