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doi: 10.3389/fphys.2025.1497566 Received 17 September 2024 Accepted 22 January 2025 Published 10 February 2025 Volume 16 - 2025 Edited by Hongxiang Hui, Monterey Park, United States Reviewed by Phiwayinkosi V

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Thus, although E 2 causes genetic changes conducive to its own inactivation, the decrease in estrogenic activity yields a toxicologically active metabolite that constitutes an additional pathway of estradiol-dependent carcinogenesis

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Larsen ST, Verder H, Nielsen GD (2012) Airway effects of inhaled quaternary ammonium compounds in mice