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It is important to note that the effect of ROS in circulating or infiltrating immune cells depends on the site of production, especially in case of autoimmunity where ROS induce Treg activation while limiting T cell proliferation and cytokine production [108,109,110,111], resulting in dampened disease activity

This was different to the pattern in the brain in which Bmal1 was more highly expressed compared to Clock

QW: Data curation, Methodology, Supervision, Writing review & editing

Note that we analyzed RPE1 cells in the current study and not HeLa cells, and perfect overlap is therefore not to be expected due to significant differences in protein abundances and hence phospho-signaling network activities between cell lines 23

Keep the needle in the vial

1981) One reported case required 0.5-2.4 mg/kg/hr, I.V