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In senescent endothelial cells induced by OGD, treatment with FOXO4-DRI led to a significant increase in the expression of BAX and cleaved caspase-3 (c-Caspase-3), while the expression of BCL2 notably decreased

Notably, the majority of checkpoint-oriented AD models still lack measurement of ferroptosis-defining hallmarks or validation using ferroptosis-selective rescue paradigms (see Table 2)

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Potier B et al (2010) Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

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