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GST is catalyzing S-conjugation reaction between the thiol group of tri-peptide glutathione, GSH (Glu-Cys-Gly) and electrophilic moiety in the hydrophobic and toxic substrates [14]

Cross-disease comparisons suggest that these modules recur across different organ niches, but their net effects are markedly context-dependent and are jointly regulated by disease stage (acute inflammation versus chronic tissue remodeling), tissue compartment (peripheral blood versus lesional tissue), as well as the spectrum of stimuli and therapeutic exposure, thereby leading to inconsistent directional outcomes of the same pathway across different models and time windows

2019), but the pathophysiological mechanisms have not been explored in detail (Hannun and Obeid 2018)

Unlike GSTM1 and GSTT1 , however, where common polymorphisms result in complete gene deletions (Board, 1981), variant GSTP1 alleles differ from the consensus reference sequence by single amino-acid substitutions, resulting in less pronounced, less frequent and less well-characterised phenotypes (Peklak-Scott et al, 2008)

10.1093/bioinformatics/bts174 Bioinformatics 78 PhamV

They increase oxidative stress, shorten telomeres faster, impair GH signaling, and blunt the cellular response to peptide therapy